5CR1

Crystal structure of TTR/resveratrol/T4 complex

Summary for 5CR1

• Entry DOI: 10.2210/pdb5cr1/pdb
• Related: 5AKS 5AKT 5AL0 5AL8
• Descriptor: Transthyretin, 3,5,3',5'-TETRAIODO-L-THYRONINE, RESVERATROL, ... (4 entities in total)
• Functional Keywords: amyloid, fibrillogenesis, fibrillogenesis inhibitors, polyphenols, polyphenol metabolites, transthyretin, negative cooperativity, transport protein
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 26359.39

Authors

Zanotti, G.,Florio, P.,Folli, C.,Cianci, M.,Del Rio, D.,Berni, R. (deposition date: 2015-07-22, release date: 2015-10-21, Last modification date: 2024-01-10)

• Primary citation: Florio, P.,Folli, C.,Cianci, M.,Del Rio, D.,Zanotti, G.,Berni, R.; Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and Their Metabolites.; J.Biol.Chem., 290:29769-29780, 2015; PubMed: 26468275; DOI: 10.1074/jbc.M115.690172

Experimental method

X-RAY DIFFRACTION (1.545 Å)