5COO
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-085
Summary for 5COO
Entry DOI | 10.2210/pdb5coo/pdb |
Related | 4HLA 5COK 5CON |
Descriptor | HIV-1 protease, (3R,3aS,4S,7aS)-3-hydroxyhexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-3-hydroxy-1-(4-methoxyphenyl)-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}butan-2-yl]carbamate (3 entities in total) |
Functional Keywords | grl-085, hiv-1 protease, protease-inhibitor, darunavir, tp-thf, nonpeptidic, hydroxyl, o-methoxy., hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22228.27 |
Authors | Yedidi, R.S.,Hayashi, H.,Aoki, M.,Das, D.,Ghosh, A.K.,Mitsuya, H. (deposition date: 2015-07-20, release date: 2016-01-13, Last modification date: 2024-03-06) |
Primary citation | Aoki, M.,Hayashi, H.,Yedidi, R.S.,Martyr, C.D.,Takamatsu, Y.,Aoki-Ogata, H.,Nakamura, T.,Nakata, H.,Das, D.,Yamagata, Y.,Ghosh, A.K.,Mitsuya, H. C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir. J.Virol., 90:2180-2194, 2015 Cited by PubMed: 26581995DOI: 10.1128/JVI.01829-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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