5CGD
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242)
Summary for 5CGD
Entry DOI | 10.2210/pdb5cgd/pdb |
Related | 4OO9 5CGC |
Descriptor | Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, OLEIC ACID, 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile, ... (4 entities in total) |
Functional Keywords | 7tm, receptor, gpcr, membrane-protein, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 51243.09 |
Authors | Christopher, J.A.,Aves, S.J.,Bennett, K.A.,Dore, A.S.,Errey, J.C.,Jazayeri, A.,Marshall, F.H.,Okrasa, K.,Serrano-Vega, M.J.,Tehan, B.G.,Wiggin, G.R.,Congreve, M. (deposition date: 2015-07-09, release date: 2015-08-12, Last modification date: 2024-01-10) |
Primary citation | Christopher, J.A.,Aves, S.J.,Bennett, K.A.,Dore, A.S.,Errey, J.C.,Jazayeri, A.,Marshall, F.H.,Okrasa, K.,Serrano-Vega, M.J.,Tehan, B.G.,Wiggin, G.R.,Congreve, M. Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). J.Med.Chem., 58:6653-6664, 2015 Cited by PubMed: 26225459DOI: 10.1021/acs.jmedchem.5b00892 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.603 Å) |
Structure validation
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