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5CGC

Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile

Summary for 5CGC
Entry DOI10.2210/pdb5cgc/pdb
Related4OO9
DescriptorMetabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, OLEIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
Functional Keywords7tm, receptor, gpcr, membrane-protein, signaling protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains1
Total formula weight51427.30
Authors
Christopher, J.A.,Aves, S.J.,Bennett, K.A.,Dore, A.S.,Errey, J.C.,Jazayeri, A.,Marshall, F.H.,Okrasa, K.,Serrano-Vega, M.J.,Tehan, B.G.,Wiggin, G.R.,Congreve, M. (deposition date: 2015-07-09, release date: 2015-08-12, Last modification date: 2024-01-10)
Primary citationChristopher, J.A.,Aves, S.J.,Bennett, K.A.,Dore, A.S.,Errey, J.C.,Jazayeri, A.,Marshall, F.H.,Okrasa, K.,Serrano-Vega, M.J.,Tehan, B.G.,Wiggin, G.R.,Congreve, M.
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
J.Med.Chem., 58:6653-6664, 2015
Cited by
PubMed: 26225459
DOI: 10.1021/acs.jmedchem.5b00892
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.101 Å)
Structure validation

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