5CGC

Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008152	biological_process	metabolic process
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue OLA A 4001

Chain	Residue
A	ASN737
A	LEU744
A	GLY748
A	CYS782
A	TRP785
A	PHE793

---

site_id	AC2
Number of Residues	4
Details	binding site for residue OLA A 4002

Chain	Residue
A	OLA4004
A	SER568
A	PRO569
A	VAL570

---

site_id	AC3
Number of Residues	3
Details	binding site for residue OLA A 4003

Chain	Residue
A	TYR645
A	ILE649
A	PHE712

---

site_id	AC4
Number of Residues	4
Details	binding site for residue OLA A 4004

Chain	Residue
A	PHE633
A	ILE636
A	OLA4002
A	HOH4106

---

site_id	AC5
Number of Residues	7
Details	binding site for residue MES A 4005

Chain	Residue
A	TYR730
A	ASN796
A	TYR797
A	LYS798
A	ILE799
A	TYR1139
A	LYS1147

---

site_id	AC6
Number of Residues	14
Details	binding site for residue 51D A 4006

Chain	Residue
A	GLY624
A	ILE625
A	GLY628
A	ILE651
A	SER654
A	PRO655
A	SER658
A	LEU744
A	TRP785
A	SER805
A	VAL806
A	SER809
A	ALA810
A	HOH4126

---

Functional Information from PROSITE/UniProt

site_id	PS00981
Number of Residues	11
Details	G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKyIAFTM

Chain	Residue	Details
A	PHE768-MET778

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	ILE581-ILE603

---

site_id	SWS_FT_FI2
Number of Residues	21
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25042998

Chain	Residue	Details
A	TYR604-SER613
A	LYS760-LYS772

---

site_id	SWS_FT_FI3
Number of Residues	22
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	SER614-ILE636

---

site_id	SWS_FT_FI4
Number of Residues	31
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:25042998

Chain	Residue	Details
A	ALA637-CYS644
A	GLU715-ASN737
A	ASN796-LYS798

---

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	TYR645-TYR667

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	LEU694-MET714

---

site_id	SWS_FT_FI7
Number of Residues	21
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	LEU738-PHE759

---

site_id	SWS_FT_FI8
Number of Residues	22
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	TYR773-SER795

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	ILE799-PRO820

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN734

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	GLU1011

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	ASP1020

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	LEU1032
A	PHE1104

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	BINDING: BINDING => ECO:0000303|PubMed:7831309

Chain	Residue	Details
A	SER1117
A	ASN1132

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU1011	proton shuttle (general acid/base)
A	ASP1020	covalent catalysis

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