5CFW
Selective pharmacological inhibition of the CREB binding protein bromodomain regulates inflammatory cytokines in macrophages and RGS4 in neurons
Summary for 5CFW
Entry DOI | 10.2210/pdb5cfw/pdb |
Related | 5CGP |
Descriptor | Bromodomain-containing protein 4, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[2-(4-methoxyphenyl)ethyl]-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole (3 entities in total) |
Functional Keywords | inhibitor complex, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15559.95 |
Authors | Chekler, E.L.,Jones, L.H. (deposition date: 2015-07-08, release date: 2016-04-20, Last modification date: 2023-09-27) |
Primary citation | Chekler, E.L.,Pellegrino, J.A.,Lanz, T.A.,Denny, R.A.,Flick, A.C.,Coe, J.,Langille, J.,Basak, A.,Liu, S.,Stock, I.A.,Sahasrabudhe, P.,Bonin, P.D.,Lee, K.,Pletcher, M.T.,Jones, L.H. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem.Biol., 22:1588-1596, 2015 Cited by PubMed: 26670081DOI: 10.1016/j.chembiol.2015.10.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.15 Å) |
Structure validation
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