5CF0
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6
Summary for 5CF0
Entry DOI | 10.2210/pdb5cf0/pdb |
Descriptor | Heat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(isoquinolin-4-yl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl}cyclopropanecarboxamide (3 entities in total) |
Functional Keywords | heat shock protein 90, n-terminal domain, inhibitor, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 26150.28 |
Authors | |
Primary citation | Li, J.,Shi, F.,Chen, D.-Q.,Cao, H.-L.,Xiong, B.,Shen, J.-K.,He, J.-H. FS23 binds to the N-terminal domain of human Hsp90: A novel small inhibitor for Hsp90 Nucl.Sci.Tech., 26:060502-060502, 2015 Cited by DOI: 10.13538/j.1001-8042/nst.26.060503PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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