5CBS

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution

Summary for 5CBS

Entry DOI	10.2210/pdb5cbs/pdb
Descriptor	Glutamate receptor 2,Glutamate receptor 2, (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid, SULFATE ION, ... (7 entities in total)
Functional Keywords	ampa receptor ligand-binding domain, glua2-s1s2j, antagonist, membrane protein, signaling protein
Biological source	Rattus norvegicus (Rat) More
Cellular location	Cell membrane ; Multi-pass membrane protein : P19491
Total number of polymer chains	4
Total formula weight	120377.48
Authors	Frydenvang, K.,Kastrup, J.S. (deposition date: 2015-07-01, release date: 2015-12-30, Last modification date: 2024-01-10)
Primary citation	Szymanska, E.,Frydenvang, K.,Pickering, D.S.,Krintel, C.,Nielsen, B.,Kooshki, A.,Zachariassen, L.G.,Olsen, L.,Kastrup, J.S.,Johansen, T.N. Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. J.Med.Chem., 59:448-461, 2016 Cited by PubMed: 26653877 DOI: 10.1021/acs.jmedchem.5b01666 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.801 Å)

Structure validation