5CBS
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutamate receptor 2,Glutamate receptor 2 | polymer | 264 | 29278.7 | 4 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | CA, E, M, V (D, A, B, C) | (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid | non-polymer | 257.3 | 4 | Chemie (E42) | |||
| 3 | DA, EA, F, FA, G... (D, A, B, C) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 4 | GA, H, HA, I, IA... (D, A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 5 | AA, L, U, Z (C, A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | BA (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | LA, MA, NA, OA (A, B, C, D) | water | water | 18.0 | 1406 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 114 (UniProt: P19491)
A, B, C, D: 117 - 261 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ala -1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 115 | - | linker |
| Thr 116 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 117114.9 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 3262.5 | |
| All* | Total formula weight | 120377.5 |
