5C29
PDE10 complexed with 6-chloro-2-cyclopropyl-5-methyl-N-propyl-pyrimidin-4-amine
Summary for 5C29
Entry DOI | 10.2210/pdb5c29/pdb |
Related | 5C1W 5C28 5C2A 5C2E 5C2H |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 83396.15 |
Authors | |
Primary citation | Shipe, W.D.,Sharik, S.S.,Barrow, J.C.,McGaughey, G.B.,Theberge, C.R.,Uslaner, J.M.,Yan, Y.,Renger, J.J.,Smith, S.M.,Coleman, P.J.,Cox, C.D. Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis. J.Med.Chem., 58:7888-7894, 2015 Cited by PubMed: 26378882DOI: 10.1021/acs.jmedchem.5b00983 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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