5BUH
Influenza PB2 bound to a hydroxymethyl azaindole inhibitor
Summary for 5BUH
Entry DOI | 10.2210/pdb5buh/pdb |
Descriptor | Polymerase basic protein 2, N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide (3 entities in total) |
Functional Keywords | small molecule inhibitor, polymerase, influenza, immune system |
Biological source | Influenza A virus |
Cellular location | Virion : Q30NP1 |
Total number of polymer chains | 1 |
Total formula weight | 19645.83 |
Authors | Jacobs, M.D. (deposition date: 2015-06-03, release date: 2016-06-08, Last modification date: 2024-03-06) |
Primary citation | Bandarage, U.K.,Clark, M.P.,Perola, E.,Gao, H.,Jacobs, M.D.,Tsai, A.,Gillespie, J.,Kennedy, J.M.,Maltais, F.,Ledeboer, M.W.,Davies, I.,Gu, W.,Byrn, R.A.,Nti Addae, K.,Bennett, H.,Leeman, J.R.,Jones, S.M.,O'Brien, C.,Memmott, C.,Bennani, Y.,Charifson, P.S. Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza. ACS Med Chem Lett, 8:261-265, 2017 Cited by PubMed: 28197323DOI: 10.1021/acsmedchemlett.6b00487 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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