5BRY

HIV-1 wild Type protease with GRL-011-11A (a methylamine bis-Tetrahydrofuran P2-Ligand, sulfonamide isostere derivate)

Summary for 5BRY

Entry DOI	10.2210/pdb5bry/pdb
Related	2IEN 3QAA 5BS4
Descriptor	Protease, SODIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 BH10 (HIV-1)
Total number of polymer chains	2
Total formula weight	22225.41
Authors	Wang, Y.-F.,Agniswamy, J.,Weber, I.T. (deposition date: 2015-06-01, release date: 2015-09-09, Last modification date: 2023-09-27)
Primary citation	Ghosh, A.K.,Martyr, C.D.,Osswald, H.L.,Sheri, V.R.,Kassekert, L.A.,Chen, S.,Agniswamy, J.,Wang, Y.F.,Hayashi, H.,Aoki, M.,Weber, I.T.,Mitsuya, H. Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies. J.Med.Chem., 58:6994-7006, 2015 Cited by PubMed: 26306007 DOI: 10.1021/acs.jmedchem.5b00900 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.34 Å)

Structure validation