5BO1

Crystal structure of a human Jag1 fragment in complex with an anti-Jag1 Fab

Summary for 5BO1

Entry DOI	10.2210/pdb5bo1/pdb
Descriptor	Protein jagged-1, Fab heavy chain, Fab light chain, ... (5 entities in total)
Functional Keywords	jag, notch, antagonist, signaling protein-immune system complex, signaling protein/immune system
Biological source	Homo sapiens (Human) More
Cellular location	Membrane; Single-pass type I membrane protein: P78504
Total number of polymer chains	6
Total formula weight	126272.72
Authors	Payandeh, J.,de Leon-Boenig, G. (deposition date: 2015-05-26, release date: 2015-11-18, Last modification date: 2023-09-27)
Primary citation	Lafkas, D.,Shelton, A.,Chiu, C.,de Leon Boenig, G.,Chen, Y.,Stawicki, S.S.,Siltanen, C.,Reichelt, M.,Zhou, M.,Wu, X.,Eastham-Anderson, J.,Moore, H.,Roose-Girma, M.,Chinn, Y.,Hang, J.Q.,Warming, S.,Egen, J.,Lee, W.P.,Austin, C.,Wu, Y.,Payandeh, J.,Lowe, J.B.,Siebel, C.W. Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung. Nature, 528:127-131, 2015 Cited by PubMed: 26580007 DOI: 10.1038/nature15715 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.56 Å)

Structure validation