5B71

Crystal structure of complement C5 in complex with SKY59

Summary for 5B71

• Entry DOI: 10.2210/pdb5b71/pdb
• Descriptor: SKY59 Fab light chain, SKY59 Fab heavy chain, Complement C5 beta chain, ... (4 entities in total)
• Functional Keywords: ph-dependent, recycling antibody, immune system, complement c5, fab, complex
• Biological source: Homo sapiens; More
• Cellular location: Secreted: P01031
• Total number of polymer chains: 6
• Total formula weight: 119495.17

Authors

Irie, M.,Shimizu, Y.,Sampei, Z.,Fukuzawa, T. (deposition date: 2016-06-03, release date: 2017-05-03, Last modification date: 2023-11-08)

• Primary citation: Fukuzawa, T.,Sampei, Z.,Haraya, K.,Ruike, Y.,Shida-Kawazoe, M.,Shimizu, Y.,Gan, S.W.,Irie, M.,Tsuboi, Y.,Tai, H.,Sakiyama, T.,Sakamoto, A.,Ishii, S.,Maeda, A.,Iwayanagi, Y.,Shibahara, N.,Shibuya, M.,Nakamura, G.,Nambu, T.,Hayasaka, A.,Mimoto, F.,Okura, Y.,Hori, Y.,Habu, K.,Wada, M.,Miura, T.,Tachibana, T.,Honda, K.,Tsunoda, H.,Kitazawa, T.,Kawabe, Y.,Igawa, T.,Hattori, K.,Nezu, J.; Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.; Sci Rep, 7:1080-1080, 2017; PubMed: 28439081; DOI: 10.1038/s41598-017-01087-7

Experimental method

X-RAY DIFFRACTION (2.11 Å)