5AGS
Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct 3-(Aminomethyl)-4-bromo-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP
5AGS の概要
エントリーDOI | 10.2210/pdb5ags/pdb |
関連するPDBエントリー | 5AGR 5AGT |
分子名称 | LEUCYL-TRNA SYNTHETASE, METHIONINE, 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE, ... (4 entities in total) |
機能のキーワード | ligase, m.tuberculosis, leucine-trna ligase activity, atp + l-leucine + trna(leu) gives amp + diphosphate + l-leucyl- trna(leu) aminoacyl-trna editing activity, aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of leurs |
由来する生物種 | MYCOBACTERIUM TUBERCULOSIS |
細胞内の位置 | Cytoplasm : P9WFV1 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 25655.10 |
構造登録者 | Palencia, A.,Li, X.,Alley, M.R.K.,Ding, C.,Easom, E.E.,Hernandez, V.,Meewan, M.,Mohan, M.,Rock, F.L.,Franzblau, S.G.,Wang, Y.,Lenaerts, A.J.,Parish, T.,Cooper, C.B.,Waters, M.G.,Ma, Z.,Mendoza, A.,Barros, D.,Cusack, S.,Plattner, J.J. (登録日: 2015-02-03, 公開日: 2016-03-09, 最終更新日: 2024-01-10) |
主引用文献 | Palencia, A.,Li, X.,Bu, W.,Choi, W.,Ding, C.Z.,Easom, E.E.,Feng, L.,Hernandez, V.,Houston, P.,Liu, L.,Meewan, M.,Mohan, M.,Rock, F.L.,Sexton, H.,Zhang, S.,Zhou, Y.,Wan, B.,Wang, Y.,Franzblau, S.G.,Woolhiser, L.,Gruppo, V.,Lenaerts, A.J.,O'Malley, T.,Parish, T.,Cooper, C.B.,Waters, M.G.,Ma, Z.,Ioerger, T.R.,Sacchettini, J.C.,Rullas, J.,Angulo-Barturen, I.,Perez-Herran, E.,Mendoza, A.,Barros, D.,Cusack, S.,Plattner, J.J.,Alley, M.R.K. Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60:6271-, 2016 Cited by PubMed: 27503647DOI: 10.1128/AAC.01339-16 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.47 Å) |
構造検証レポート
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