5AFG
Structure of the Stapled Peptide Bound to Mdm2
Summary for 5AFG
Entry DOI | 10.2210/pdb5afg/pdb |
Descriptor | E3 UBIQUITIN-PROTEIN LIGASE MDM2, STAPLED PEPTIDE, 1,8-DIETHYL-1,8-DIHYDRODIBENZO[3,4:7,8][1,2,3]TRIAZOLO[4',5':5,6]CYCLOOCTA[1,2-D][1,2,3]TRIAZOLE, ... (4 entities in total) |
Functional Keywords | ligase, mdm2 |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 12865.93 |
Authors | Lau, Y.H.,Wu, Y.,Rossmann, M.,de Andrade, P.,Tan, Y.S.,McKenzie, G.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R. (deposition date: 2015-01-22, release date: 2016-01-27, Last modification date: 2024-01-10) |
Primary citation | Lau, Y.H.,Wu, Y.,Rossmann, M.,Tan, B.X.,De Andrade, P.,Tan, Y.S.,Verma, C.,Mckenzie, G.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R. Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides. Angew.Chem.Int.Ed.Engl., 54:15410-, 2015 Cited by PubMed: 26768531DOI: 10.1002/ANIE.201508416 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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