5AFG
Structure of the Stapled Peptide Bound to Mdm2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 UBIQUITIN-PROTEIN LIGASE MDM2 | polymer | 97 | 11082.0 | 1 | UniProt (Q00987) Pfam (PF02201) | HOMO SAPIENS (HUMAN) | |
| 2 | B (B) | STAPLED PEPTIDE | polymer | 12 | 1441.6 | 1 | SYHTHETIC CONSTRUCT | ||
| 3 | C (B) | 1,8-DIETHYL-1,8-DIHYDRODIBENZO[3,4:7,8][1,2,3]TRIAZOLO[4',5':5,6]CYCLOOCTA[1,2-D][1,2,3]TRIAZOLE | non-polymer | 342.4 | 1 | Chemie (P07) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A: 17 - 108 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| Pro 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Ala 69 | Glu 69 | engineered mutation |
| Ala 70 | Lys 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 12523.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 342.4 | |
| All* | Total formula weight | 12865.9 |
