5AE9
Crystal structure of mouse PI3 kinase delta in complex with GSK2292767
Summary for 5AE9
Entry DOI | 10.2210/pdb5ae9/pdb |
Related | 5AE8 |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, N-[5-[4-(5-{[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]METHYL}-1,3-OXAZOL-2-YL)-1H-INDAZOL-6-YL]-2-(METHYLOXY)-3-PYRIDINYL]METHANESULFONAMIDE (3 entities in total) |
Functional Keywords | transferase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 108336.25 |
Authors | Down, K.D.,Amour, A.,Baldwin, I.R.,Cooper, A.W.J.,Deakin, A.M.,Felton, L.M.,Guntrip, S.B.,Hardy, C.,Harrison, Z.A.,Jones, K.L.,Jones, P.,Keeling, S.E.,Le, J.,Livia, S.,Lucas, F.,Lunniss, C.J.,Parr, N.J.,Robinson, E.,Rowland, P.,Smith, S.,Thomas, D.A.,Vitulli, G.,Washio, Y.,Hamblin, N. (deposition date: 2015-08-26, release date: 2015-09-16, Last modification date: 2024-06-19) |
Primary citation | Down, K.,Amour, A.,Baldwin, I.R.,Cooper, A.W.J.,Deakin, A.M.,Felton, L.M.,Guntrip, S.B.,Hardy, C.,Harrison, Z.A.,Jones, K.L.,Jones, P.,Keeling, S.E.,Le, J.,Livia, S.,Lucas, F.,Lunniss, C.J.,Parr, N.J.,Robinson, E.,Rowland, P.,Smith, S.,Thomas, D.A.,Vitulli, G.,Washio, Y.,Hamblin, J.N. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase Gamma for the Treatment of Respiratory Disease. J.Med.Chem., 58:7381-, 2015 Cited by PubMed: 26301626DOI: 10.1021/ACS.JMEDCHEM.5B00767 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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