4ZYP

Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein

Summary for 4ZYP

• Entry DOI: 10.2210/pdb4zyp/pdb
• Related: 4ZYK
• Descriptor: Fusion glycoprotein F0,Fibritin, Motavizumab antibody Fab heavy chain, Motavizumab antibody light chain, ... (5 entities in total)
• Functional Keywords: ig domain, fab, immune system, fusion, respiratory syncytial virus, prefusion
• Biological source: Human respiratory syncytial virus A (strain A2); More
• Total number of polymer chains: 15
• Total formula weight: 451609.35

Authors

Gilman, M.S.A.,McLellan, J.S. (deposition date: 2015-05-21, release date: 2015-07-29, Last modification date: 2023-09-27)

• Primary citation: Gilman, M.S.,Moin, S.M.,Mas, V.,Chen, M.,Patel, N.K.,Kramer, K.,Zhu, Q.,Kabeche, S.C.,Kumar, A.,Palomo, C.,Beaumont, T.,Baxa, U.,Ulbrandt, N.D.,Melero, J.A.,Graham, B.S.,McLellan, J.S.; Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.; Plos Pathog., 11:e1005035-e1005035, 2015; PubMed: 26161532; DOI: 10.1371/journal.ppat.1005035

Experimental method

X-RAY DIFFRACTION (5.5 Å)