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4ZY5

Crystal Structure of p21-activated kinase 1 in complex with an inhibitor compound 17

Summary for 4ZY5
Entry DOI10.2210/pdb4zy5/pdb
Related4ZY4 4ZY6 5BMS
DescriptorSerine/threonine-protein kinase PAK 1, N~2~-[(trans-4-aminocyclohexyl)methyl]-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, SULFATE ION, ... (5 entities in total)
Functional Keywordskinase, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q13153
Total number of polymer chains2
Total formula weight68072.21
Authors
Rouge, L.,Wang, W. (deposition date: 2015-05-21, release date: 2015-07-01, Last modification date: 2015-07-15)
Primary citationCrawford, J.J.,Lee, W.,Aliagas, I.,Mathieu, S.,Hoeflich, K.P.,Zhou, W.,Wang, W.,Rouge, L.,Murray, L.,La, H.,Liu, N.,Fan, P.W.,Cheong, J.,Heise, C.E.,Ramaswamy, S.,Mintzer, R.,Liu, Y.,Chao, Q.,Rudolph, J.
Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.
J.Med.Chem., 58:5121-5136, 2015
Cited by
PubMed: 26030457
DOI: 10.1021/acs.jmedchem.5b00572
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

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