4ZX6
X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10s
4ZX6 の概要
エントリーDOI | 10.2210/pdb4zx6/pdb |
関連するPDBエントリー | 3EBG 4ZW3 4ZW5 4ZW6 4ZW7 4ZW8 4ZX3 4ZX4 4ZX5 |
分子名称 | M1 family aminopeptidase, ZINC ION, N-{(1R)-2-(hydroxyamino)-1-[3'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl]-2-oxoethyl}-2,2-dimethylpropanamide, ... (7 entities in total) |
機能のキーワード | m1 alanyl-aminopeptidase, protease, inhibitor, hydroxamic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Plasmodium falciparum (isolate FcB1 / Columbia) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 104639.49 |
構造登録者 | |
主引用文献 | Drinkwater, N.,Vinh, N.B.,Mistry, S.N.,Bamert, R.S.,Ruggeri, C.,Holleran, J.P.,Loganathan, S.,Paiardini, A.,Charman, S.A.,Powell, A.K.,Avery, V.M.,McGowan, S.,Scammells, P.J. Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110:43-64, 2016 Cited by PubMed: 26807544DOI: 10.1016/j.ejmech.2016.01.015 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.05 Å) |
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