4ZVV

Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140

Summary for 4ZVV

Entry DOI	10.2210/pdb4zvv/pdb
Descriptor	L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ... (5 entities in total)
Functional Keywords	oxidoreductase inhibitor complex, ldha-g02792140, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P00338
Total number of polymer chains	4
Total formula weight	152261.01
Authors	Li, Y.,Chen, Z.,Eigenbrot, C. (deposition date: 2015-05-18, release date: 2016-05-18, Last modification date: 2023-09-27)
Primary citation	Boudreau, A.,Purkey, H.E.,Hitz, A.,Robarge, K.,Peterson, D.,Labadie, S.,Kwong, M.,Hong, R.,Gao, M.,Del Nagro, C.,Pusapati, R.,Ma, S.,Salphati, L.,Pang, J.,Zhou, A.,Lai, T.,Li, Y.,Chen, Z.,Wei, B.,Yen, I.,Sideris, S.,McCleland, M.,Firestein, R.,Corson, L.,Vanderbilt, A.,Williams, S.,Daemen, A.,Belvin, M.,Eigenbrot, C.,Jackson, P.K.,Malek, S.,Hatzivassiliou, G.,Sampath, D.,Evangelista, M.,O'Brien, T. Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat.Chem.Biol., 12:779-786, 2016 Cited by PubMed: 27479743 DOI: 10.1038/nchembio.2143 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation