4ZVV

Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140

4ZVV の概要

• エントリーDOI: 10.2210/pdb4zvv/pdb
• 分子名称: L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: oxidoreductase inhibitor complex, ldha-g02792140, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P00338
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 152261.01

構造登録者

Li, Y.,Chen, Z.,Eigenbrot, C. (登録日: 2015-05-18, 公開日: 2016-05-18, 最終更新日: 2023-09-27)

• 主引用文献: Boudreau, A.,Purkey, H.E.,Hitz, A.,Robarge, K.,Peterson, D.,Labadie, S.,Kwong, M.,Hong, R.,Gao, M.,Del Nagro, C.,Pusapati, R.,Ma, S.,Salphati, L.,Pang, J.,Zhou, A.,Lai, T.,Li, Y.,Chen, Z.,Wei, B.,Yen, I.,Sideris, S.,McCleland, M.,Firestein, R.,Corson, L.,Vanderbilt, A.,Williams, S.,Daemen, A.,Belvin, M.,Eigenbrot, C.,Jackson, P.K.,Malek, S.,Hatzivassiliou, G.,Sampath, D.,Evangelista, M.,O'Brien, T.; Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.; Nat.Chem.Biol., 12:779-786, 2016; PubMed: 27479743; DOI: 10.1038/nchembio.2143

実験手法

X-RAY DIFFRACTION (2.2 Å)