4ZUD

Crystal Structure of Human Angiotensin Receptor in Complex with Inverse Agonist Olmesartan at 2.8A resolution.

4ZUD の概要

• エントリーDOI: 10.2210/pdb4zud/pdb
• 分子名称: Chimera protein of Soluble cytochrome b562 and Type-1 angiotensin II receptor, Olmesartan (2 entities in total)
• 機能のキーワード: human angiotensin receptor at1r, bril, g protein-coupled receptor, gpcr, gpcr network, lipidic cubic phase, lcp, membrane protein, structural genomics, olmesartan, angiotensin receptor blocker, anti-hypertensive drug, psi-biology, signaling protein
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47168.54

構造登録者

Zhang, H.,Unal, H.,Desnoyer, R.,Han, G.W.,Patel, N.,Katritch, V.,Karnik, S.S.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (登録日: 2015-05-15, 公開日: 2015-10-07, 最終更新日: 2023-09-27)

• 主引用文献: Zhang, H.,Unal, H.,Desnoyer, R.,Han, G.W.,Patel, N.,Katritch, V.,Karnik, S.S.,Cherezov, V.,Stevens, R.C.; Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor.; J.Biol.Chem., 290:29127-29139, 2015; PubMed: 26420482; DOI: 10.1074/jbc.M115.689000

実験手法

X-RAY DIFFRACTION (2.8 Å)