4ZTR
Human Aurora A catalytic domain bound to FK1141
Summary for 4ZTR
| Entry DOI | 10.2210/pdb4ztr/pdb |
| Descriptor | Aurora kinase A, 6-({4-[(Z)-{(2Z)-2-[(4-ethylphenyl)imino]-3-methyl-4-oxo-1,3-thiazolidin-5-ylidene}methyl]pyridin-2-yl}amino)pyridine-3-carboxylic acid (3 entities in total) |
| Functional Keywords | aurora, kinase, inhibitor, transferase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 |
| Total number of polymer chains | 1 |
| Total formula weight | 33408.30 |
| Authors | Marcaida, M.J.,Kilchmann, F.,Schick, T.,Reymond, J.L. (deposition date: 2015-05-15, release date: 2016-07-20, Last modification date: 2024-01-10) |
| Primary citation | Kilchmann, F.,Marcaida, M.J.,Kotak, S.,Schick, T.,Boss, S.D.,Awale, M.,Gonczy, P.,Reymond, J.L. Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening. J.Med.Chem., 59:7188-7211, 2016 Cited by PubMed: 27391133DOI: 10.1021/acs.jmedchem.6b00709 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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