4ZTQ
Human Aurora A catalytic domain bound to FK932
Summary for 4ZTQ
Entry DOI | 10.2210/pdb4ztq/pdb |
Descriptor | Aurora kinase A, (2Z,5Z)-2-[(4-ethylphenyl)imino]-3-(2-methoxyethyl)-5-(pyridin-4-ylmethylidene)-1,3-thiazolidin-4-one, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total) |
Functional Keywords | aurora, kinase, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 |
Total number of polymer chains | 1 |
Total formula weight | 33434.42 |
Authors | Marcaida, M.J.,Kilchmann, F.,Schick, T.,Reymond, J.L. (deposition date: 2015-05-14, release date: 2016-07-20, Last modification date: 2024-01-10) |
Primary citation | Kilchmann, F.,Marcaida, M.J.,Kotak, S.,Schick, T.,Boss, S.D.,Awale, M.,Gonczy, P.,Reymond, J.L. Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening. J.Med.Chem., 59:7188-7211, 2016 Cited by PubMed: 27391133DOI: 10.1021/acs.jmedchem.6b00709 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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