4ZR5

Soluble rabbit neprilysin in complex with phosphoramidon

4ZR5 の概要

• エントリーDOI: 10.2210/pdb4zr5/pdb
• 関連するPDBエントリー: 4XBH
• 関連するBIRD辞書のPRD_ID: PRD_000638
• 分子名称: Neprilysin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (6 entities in total)
• 機能のキーワード: neutral endopeptidase, phosphoramidon, zn-dependent, hydrolase
• 由来する生物種: Oryctolagus cuniculus (Rabbit)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 162316.56

構造登録者

Labiuk, S.L.,Grochulski, P.,Sygusch, J. (登録日: 2015-05-11, 公開日: 2016-06-08, 最終更新日: 2024-10-23)

主引用文献

Labiuk, S.L.,Sygusch, J.,Grochulski, P.
Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan.
Acta Crystallogr.,Sect.F, 75:405-411, 2019

PubMed Abstract: Neutral endopeptidase (neprilysin; NEP) is a proteinase that cleaves a wide variety of peptides and has been implicated in Alzheimer's disease, cardiovascular conditions, arthritis and other inflammatory diseases. The structure of the soluble extracellular domain (residues 55-750) of rabbit neprilysin was solved both in its native form at 2.1 Å resolution, and bound to the inhibitors phosphoramidon and thiorphan at 2.8 and 3.0 Å resolution, respectively. Consistent with the extracellular domain of human neprilysin, the structure reveals a large central cavity which contains the active site and the location for inhibitor binding.

PubMed: 31204686
DOI: 10.1107/S2053230X19006046

実験手法

X-RAY DIFFRACTION (2.8016 Å)