4ZQT

Crystal structure of PfA-M1 with virtual ligand inhibitor

4ZQT の概要

• エントリーDOI: 10.2210/pdb4zqt/pdb
• 分子名称: M1 family aminopeptidase, (2R)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, ZINC ION, ... (6 entities in total)
• 機能のキーワード: aminopeptidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Plasmodium falciparum 3D7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 104204.81

構造登録者

Ruggeri, C.,Drinkwater, N.,McGowan, S. (登録日: 2015-05-11, 公開日: 2015-10-07, 最終更新日: 2023-09-27)

• 主引用文献: Ruggeri, C.,Drinkwater, N.,Sivaraman, K.K.,Bamert, R.S.,McGowan, S.,Paiardini, A.; Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.; Plos One, 10:e0138957-e0138957, 2015; PubMed: 26406322; DOI: 10.1371/journal.pone.0138957

実験手法

X-RAY DIFFRACTION (1.981 Å)