4ZQP
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor MAD1
4ZQP の概要
エントリーDOI | 10.2210/pdb4zqp/pdb |
関連するPDBエントリー | 4ZQM 4ZQN 4ZQO |
分子名称 | Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, 5'-O-({1-[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]-1H-1,2,3-triazol-4-yl}methyl)adenosine, ... (8 entities in total) |
機能のキーワード | impdh, delta cbs, mad1, structural genomics, center for membrane proteins of infectious diseases, center for structural genomics of infectious diseases, csgid, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 42901.69 |
構造登録者 | Kim, Y.,Makowska-Grzyska, M.,Gu, M.,Kavitha, M.,Hedstrom, L.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2015-05-10, 公開日: 2015-06-17, 最終更新日: 2024-05-22) |
主引用文献 | Makowska-Grzyska, M.,Kim, Y.,Gorla, S.K.,Wei, Y.,Mandapati, K.,Zhang, M.,Maltseva, N.,Modi, G.,Boshoff, H.I.,Gu, M.,Aldrich, C.,Cuny, G.D.,Hedstrom, L.,Joachimiak, A. Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. Plos One, 10:e0138976-e0138976, 2015 Cited by PubMed: 26440283DOI: 10.1371/journal.pone.0138976 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
構造検証レポート
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