4ZQN

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor P41

Summary for 4ZQN

• Entry DOI: 10.2210/pdb4zqn/pdb
• Related: 4ZQM 4ZQO 4ZQP 4ZQR
• Descriptor: Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, 2-chloro-N,N-dimethyl-5-[({2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}carbamoyl)amino]benzamide, ... (4 entities in total)
• Functional Keywords: impdh, delta cbs, structural genomics, center for structural genomics of infectious diseases, csgid, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 1
• Total formula weight: 42390.74

Authors

Kim, Y.,Makowska-Grzyska, M.,Gu, M.,Kavitha, M.,Hedstrom, L.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2015-05-10, release date: 2015-06-17, Last modification date: 2022-03-30)

• Primary citation: Makowska-Grzyska, M.,Kim, Y.,Gorla, S.K.,Wei, Y.,Mandapati, K.,Zhang, M.,Maltseva, N.,Modi, G.,Boshoff, H.I.,Gu, M.,Aldrich, C.,Cuny, G.D.,Hedstrom, L.,Joachimiak, A.; Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds.; Plos One, 10:e0138976-e0138976, 2015; PubMed: 26440283; DOI: 10.1371/journal.pone.0138976

Experimental method

X-RAY DIFFRACTION (2 Å)