4ZO1

Crystal Structure of the T3-bound TR-beta Ligand-binding Domain in complex with RXR-alpha

4ZO1 の概要

• エントリーDOI: 10.2210/pdb4zo1/pdb
• 分子名称: Thyroid hormone receptor beta, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, ligand binding, protein-ligand complex, protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: P10828 P19793
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 55562.81

構造登録者

Bruning, J.B.,Kojetin, D.J.,Matta-Camacho, E.,Hughes, T.S.,Srinivasan, S.,Nwachukwu, J.C.,Cavett, V.,Nowak, J.,Chalmers, M.J.,Marciano, D.P.,Kamenecka, T.M.,Rance, M.,Shulman, A.I.,Mangelsdorf, D.J.,Griffin, P.R.,Nettles, K.W. (登録日: 2015-05-05, 公開日: 2015-09-02, 最終更新日: 2023-11-15)

• 主引用文献: Kojetin, D.J.,Matta-Camacho, E.,Hughes, T.S.,Srinivasan, S.,Nwachukwu, J.C.,Cavett, V.,Nowak, J.,Chalmers, M.J.,Marciano, D.P.,Kamenecka, T.M.,Shulman, A.I.,Rance, M.,Griffin, P.R.,Bruning, J.B.,Nettles, K.W.; Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.; Nat Commun, 6:8013-8013, 2015; PubMed: 26289479; DOI: 10.1038/ncomms9013

実験手法

X-RAY DIFFRACTION (3.221 Å)