4ZNN

MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56

Summary for 4ZNN

• Entry DOI: 10.2210/pdb4znn/pdb
• Related: 4RIL
• EMDB information: 3001
• Descriptor: Alpha-synuclein (2 entities in total)
• Functional Keywords: amyloid, alpha-synuclein, parkinson's disease, toxic core, nacore, lipid binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 940.07

Authors

Rodriguez, J.A.,Ivanova, M.,Sawaya, M.R.,Cascio, D.,Reyes, F.,Shi, D.,Johnson, L.,Guenther, E.,Sangwan, S.,Hattne, J.,Nannenga, B.,Brewster, A.S.,Messerschmidt, M.,Boutet, S.,Sauter, N.K.,Gonen, T.,Eisenberg, D.S. (deposition date: 2015-05-05, release date: 2015-09-09, Last modification date: 2024-03-06)

• Primary citation: Rodriguez, J.A.,Ivanova, M.I.,Sawaya, M.R.,Cascio, D.,Reyes, F.E.,Shi, D.,Sangwan, S.,Guenther, E.L.,Johnson, L.M.,Zhang, M.,Jiang, L.,Arbing, M.A.,Nannenga, B.L.,Hattne, J.,Whitelegge, J.,Brewster, A.S.,Messerschmidt, M.,Boutet, S.,Sauter, N.K.,Gonen, T.,Eisenberg, D.S.; Structure of the toxic core of alpha-synuclein from invisible crystals.; Nature, 525:486-490, 2015; PubMed: 26352473; DOI: 10.1038/nature15368

Experimental method

ELECTRON CRYSTALLOGRAPHY (1.41 Å)