4ZN5

YopH W354Y Yersinia enterocolitica PTPase bond with Divanadate glycerol ester in the active site

Summary for 4ZN5

• Entry DOI: 10.2210/pdb4zn5/pdb
• Related: 4YAA
• Descriptor: Tyrosine-protein phosphatase YopH, Divanadate Glycerol ester, VANADATE ION, ... (6 entities in total)
• Functional Keywords: inhibitor, phosphatase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Yersinia enterocolitica
• Total number of polymer chains: 1
• Total formula weight: 34072.91

Authors

Moise, G.E.,Johnson, S.J.,Hengge, A.C. (deposition date: 2015-05-04, release date: 2015-10-28, Last modification date: 2023-09-27)

• Primary citation: Moise, G.,Gallup, N.M.,Alexandrova, A.N.,Hengge, A.C.,Johnson, S.J.; Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites.; Biochemistry, 54:6490-6500, 2015; PubMed: 26445170; DOI: 10.1021/acs.biochem.5b00496

Experimental method

X-RAY DIFFRACTION (1.12 Å)