4ZLR

Structure of the Brat-NHL domain bound to consensus RNA motif

Summary for 4ZLR

• Entry DOI: 10.2210/pdb4zlr/pdb
• Descriptor: Brain tumor protein, RNA (5'-R(*UP*UP*GP*UP*UP*GP*UP*UP*UP*UP*UP*UP*UP*U)-3'), 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... (7 entities in total)
• Functional Keywords: nhl-domain, beta-propeller, rna binding, translational repressor, translation
• Biological source: Drosophila melanogaster (Fruit fly); More
• Cellular location: Cytoplasm : Q8MQJ9
• Total number of polymer chains: 3
• Total formula weight: 70209.95

Authors

Jakob, L.,Treiber, N.,Treiber, T.,Stotz, M.,Loedige, I.,Meister, G. (deposition date: 2015-05-01, release date: 2015-11-11, Last modification date: 2024-01-10)

• Primary citation: Loedige, I.,Jakob, L.,Treiber, T.,Ray, D.,Stotz, M.,Treiber, N.,Hennig, J.,Cook, K.B.,Morris, Q.,Hughes, T.R.,Engelmann, J.C.,Krahn, M.P.,Meister, G.; The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation.; Cell Rep, 13:1206-1220, 2015; PubMed: 26527002; DOI: 10.1016/j.celrep.2015.09.068

Experimental method

X-RAY DIFFRACTION (2.3 Å)