4ZJS

Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.

4ZJS の概要

• エントリーDOI: 10.2210/pdb4zjs/pdb
• 分子名称: Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor,Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor, 1-[(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethanone (3 entities in total)
• 機能のキーワード: anatoxin-a, nicotinic, receptor, acetylcholine, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 132041.90

構造登録者

Talley, T.T.,Bobango, J.,Wu, J.,Park, J.F.,Luo, J.,Lindsatrom, J.,Taylor, P. (登録日: 2015-04-29, 公開日: 2015-05-13, 最終更新日: 2023-09-27)

• 主引用文献: Luo, J.,Taylor, P.,Losen, M.,de Baets, M.H.,Shelton, G.D.,Lindstrom, J.; Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity.; J. Neurosci., 29:13898-13908, 2009; PubMed: 19890000; DOI: 10.1523/JNEUROSCI.2833-09.2009

実験手法

X-RAY DIFFRACTION (2.2301 Å)