4ZJD

Small heat shock protein AgsA from Salmonella typhimurium: Truncations at N- and C- termini

Summary for 4ZJD

• Entry DOI: 10.2210/pdb4zjd/pdb
• Related: 4ZJ9 4ZJA
• Descriptor: Aggregation suppressing protein (1 entity in total)
• Functional Keywords: small heat shock protein, chaperone, oligomer, crystallin
• Biological source: Salmonella enterica subsp. enterica serovar Typhimurium
• Total number of polymer chains: 6
• Total formula weight: 93758.89

Authors

Mani, N.,Suguna, K. (deposition date: 2015-04-29, release date: 2016-04-20, Last modification date: 2024-10-30)

Primary citation

Mani, N.,Bhandari, S.,Moreno, R.,Hu, L.,Prasad, B.V.,Suguna, K.
Multiple oligomeric structures of a bacterial small heat shock protein
Sci Rep, 6:24019-24019, 2016

PubMed Abstract: Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. Owing to the dynamic nature of small heat shock protein oligomers, elucidating the structural basis of chaperone action and oligomerization still remains a challenge. In order to understand the organization of sHSP oligomers, we have determined crystal structures of a small heat shock protein from Salmonella typhimurium in a dimeric form and two higher oligomeric forms: an 18-mer and a 24-mer. Though the core dimer structure is conserved in all the forms, structural heterogeneity arises due to variation in the terminal regions.

PubMed: 27053150
DOI: 10.1038/srep24019

Experimental method

X-RAY DIFFRACTION (7.5 Å)