4ZIP

HIV-1 wild Type protease with GRL-0648A (a isophthalamide-derived P2-Ligand)

Summary for 4ZIP

Entry DOI	10.2210/pdb4zip/pdb
Related	2IEN 3OK9 3QAA 4U8W
Descriptor	Protease, SODIUM ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 (HIV-1)
Total number of polymer chains	2
Total formula weight	22439.63
Authors	Wang, Y.-F.,Agniswamy, J.,Weber, I.T. (deposition date: 2015-04-28, release date: 2015-07-15, Last modification date: 2023-09-27)
Primary citation	Ghosh, A.K.,Takayama, J.,Kassekert, L.A.,Ella-Menye, J.R.,Yashchuk, S.,Agniswamy, J.,Wang, Y.F.,Aoki, M.,Amano, M.,Weber, I.T.,Mitsuya, H. Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands. Bioorg.Med.Chem.Lett., 25:4903-4909, 2015 Cited by PubMed: 26096678 DOI: 10.1016/j.bmcl.2015.05.052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.11 Å)

Structure validation