4ZHT
Crystal structure of UDP-GlcNAc 2-epimerase
Summary for 4ZHT
Entry DOI | 10.2210/pdb4zht/pdb |
Descriptor | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, URIDINE-5'-DIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE-5-N-ACETYLNEURAMINIC ACID, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, epimerase, isomerase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9Y223 |
Total number of polymer chains | 4 |
Total formula weight | 192596.48 |
Authors | Chen, S.C.,Yang, C.S.,Ko, T.P.,Chen, Y. (deposition date: 2015-04-27, release date: 2016-06-01, Last modification date: 2020-07-29) |
Primary citation | Chen, S.C.,Huang, C.H.,Lai, S.J.,Yang, C.S.,Hsiao, T.H.,Lin, C.H.,Fu, P.K.,Ko, T.P.,Chen, Y. Mechanism and inhibition of human UDP-GlcNAc 2-epimerase, the key enzyme in sialic acid biosynthesis. Sci Rep, 6:23274-23274, 2016 Cited by PubMed: 26980148DOI: 10.1038/srep23274 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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