4ZHQ
Crystal structure of Tubulin-Stathmin-TTL-MMAE Complex
Summary for 4ZHQ
Entry DOI | 10.2210/pdb4zhq/pdb |
Related | 4ZI7 4ZOL 5BMV |
Related PRD ID | PRD_002173 |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, ... (13 entities in total) |
Functional Keywords | structural protein-inhibitor complex, structural protein/inhibitor |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cytoplasm, cytoskeleton: Q2XVP4 P02554 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265947.72 |
Authors | |
Primary citation | Wang, Y.,Benz, F.W.,Wu, Y.,Wang, Q.,Chen, Y.,Chen, X.,Li, H.,Zhang, Y.,Zhang, R.,Yang, J. Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules Mol.Pharmacol., 89:233-242, 2016 Cited by PubMed: 26660762DOI: 10.1124/mol.115.100149 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
Download full validation report