4ZHM

The crystal structure of mupain-1--16-IG in complex with murinised human uPA at pH7.4

4ZHM の概要

• エントリーDOI: 10.2210/pdb4zhm/pdb
• 分子名称: mupain-1-16-IG, Urokinase-type plasminogen activator, piperidine-1-carboximidamide, ... (4 entities in total)
• 機能のキーワード: peptides inhibitor, upa, serine protease, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted: P00749
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29044.14

構造登録者

Jiang, L.,Andreasen, P.A.,Huang, M. (登録日: 2015-04-25, 公開日: 2015-09-16, 最終更新日: 2015-10-14)

• 主引用文献: Srensen, H.P.,Xu, P.,Jiang, L.,Kromann-Hansen, T.,Jensen, K.J.,Huang, M.,Andreasen, P.A.; Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions.; J.Mol.Biol., 427:3110-3122, 2015; PubMed: 26281711; DOI: 10.1016/j.jmb.2015.08.005

実験手法

X-RAY DIFFRACTION (1.9 Å)