4ZGX

Structure of aldosterone synthase (CYP11B2) in complex with (+)-(R)-N-(4-(4-chloro-3-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide

4ZGX の概要

• エントリーDOI: 10.2210/pdb4zgx/pdb
• 分子名称: Cytochrome P450 11B2, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, N-[(8R)-4-(4-chloro-3-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide, ... (4 entities in total)
• 機能のキーワード: cytochrome p450, cyp11b2, aldosterone synthase, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion membrane: P19099
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 685632.23

構造登録者

Kuglstatter, A.,Joseph, C. (登録日: 2015-04-24, 公開日: 2015-10-07, 最終更新日: 2024-05-01)

• 主引用文献: Martin, R.E.,Aebi, J.D.,Hornsperger, B.,Krebs, H.J.,Kuhn, B.,Kuglstatter, A.,Alker, A.M.,Marki, H.P.,Muller, S.,Burger, D.,Ottaviani, G.,Riboulet, W.,Verry, P.,Tan, X.,Amrein, K.,Mayweg, A.V.; Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.; J.Med.Chem., 58:8054-8065, 2015; PubMed: 26403853; DOI: 10.1021/acs.jmedchem.5b00851

実験手法

X-RAY DIFFRACTION (3.2 Å)