4ZGM

Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain

Summary for 4ZGM

Entry DOI	10.2210/pdb4zgm/pdb
Related	3IOL
Descriptor	Glucagon-like peptide 1 receptor, Semaglutide peptide backbone; 8Aib,34R-GLP-1(7-37)-OH, 3,6,9,12,15,18-hexaoxahexacosan-1-ol, ... (4 entities in total)
Functional Keywords	glp-1, receptor, complex, signaling protein
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane; Multi-pass membrane protein: P43220
Total number of polymer chains	2
Total formula weight	18516.67
Authors	Reedtz-Runge, S. (deposition date: 2015-04-23, release date: 2015-09-09, Last modification date: 2024-01-10)
Primary citation	Lau, J.,Bloch, P.,Schaffer, L.,Pettersson, I.,Spetzler, J.,Kofoed, J.,Madsen, K.,Knudsen, L.B.,McGuire, J.,Steensgaard, D.B.,Strauss, H.M.,Gram, D.X.,Knudsen, S.M.,Nielsen, F.S.,Thygesen, P.,Reedtz-Runge, S.,Kruse, T. Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. J.Med.Chem., 58:7370-7380, 2015 Cited by PubMed: 26308095 DOI: 10.1021/acs.jmedchem.5b00726 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation