4ZGA

Structural basis for inhibition of human autotaxin by four novel compounds

4ZGA の概要

• エントリーDOI: 10.2210/pdb4zga/pdb
• 関連するPDBエントリー: 4ZG6 4ZG7 4ZG9
• 分子名称: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (9 entities in total)
• 機能のキーワード: autotaxin, enpp2, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted : Q13822
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 100530.65

構造登録者

Stein, A.J.,Bain, G.,Hutchinson, J.H.,Evans, J.F. (登録日: 2015-04-22, 公開日: 2015-10-14, 最終更新日: 2020-07-29)

• 主引用文献: Stein, A.J.,Bain, G.,Prodanovich, P.,Santini, A.M.,Darlington, J.,Stelzer, N.M.,Sidhu, R.S.,Schaub, J.,Goulet, L.,Lonergan, D.,Calderon, I.,Evans, J.F.,Hutchinson, J.H.; Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.; Mol.Pharmacol., 88:982-992, 2015; PubMed: 26371182; DOI: 10.1124/mol.115.100404

実験手法

X-RAY DIFFRACTION (2.6 Å)