4ZFP
A new crystal structure for the adduct formed in the reaction between AuSac2, a cytotoxic homoleptic gold(I) compound with the saccharinate ligand, and the model protein hen egg white lysozyme
Summary for 4ZFP
| Entry DOI | 10.2210/pdb4zfp/pdb |
| Descriptor | Lysozyme C, 1,2-ETHANEDIOL, NITRATE ION, ... (5 entities in total) |
| Functional Keywords | gold compounds, gold-based drugs, protein-metallodrug interactions, metallodrugs, hydrolase |
| Biological source | Gallus gallus (Chicken) |
| Cellular location | Secreted: P00698 |
| Total number of polymer chains | 1 |
| Total formula weight | 15356.16 |
| Authors | Merlino, A. (deposition date: 2015-04-21, release date: 2015-06-24, Last modification date: 2024-01-10) |
| Primary citation | Ferraro, G.,Massai, L.,Messori, L.,Cinellu, M.A.,Merlino, A. Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme. Biometals, 28:745-754, 2015 Cited by PubMed: 26054833DOI: 10.1007/s10534-015-9863-7 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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