4ZC9

Crystal Structure of the BRD4a/DB-2-190 complex

Summary for 4ZC9

Entry DOI	10.2210/pdb4zc9/pdb
Descriptor	Bromodomain-containing protein 4, 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}butyl)acetamide (3 entities in total)
Functional Keywords	bromodomain, small-molecule complex, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15884.65
Authors	Seo, H.-S.,DeAngelo, S.,Bradner, J.E. (deposition date: 2015-04-15, release date: 2015-11-18, Last modification date: 2024-03-06)
Primary citation	Winter, G.E.,Buckley, D.L.,Paulk, J.,Roberts, J.M.,Souza, A.,Dhe-Paganon, S.,Bradner, J.E. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science, 348:1376-1381, 2015 Cited by PubMed: 25999370 DOI: 10.1126/science.aab1433 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.99 Å)

Structure validation