4ZC7
Paromomycin bound to a leishmanial ribosomal A-site
Summary for 4ZC7
Entry DOI | 10.2210/pdb4zc7/pdb |
Descriptor | RNA duplex, PAROMOMYCIN (3 entities in total) |
Functional Keywords | a-site, ribosome, paromomycin, leishmania, rna |
Biological source | synthetic construct |
Total number of polymer chains | 4 |
Total formula weight | 119473.02 |
Authors | Shalev, M.,Rozenberg, H.,Jaffe, C.L.,Adir, N.,Baasov, T. (deposition date: 2015-04-15, release date: 2015-08-26, Last modification date: 2024-01-10) |
Primary citation | Shalev, M.,Rozenberg, H.,Smolkin, B.,Nasereddin, A.,Kopelyanskiy, D.,Belakhov, V.,Schrepfer, T.,Schacht, J.,Jaffe, C.L.,Adir, N.,Baasov, T. Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics. Nucleic Acids Res., 43:8601-8613, 2015 Cited by PubMed: 26264664DOI: 10.1093/nar/gkv821 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.041 Å) |
Structure validation
Download full validation report