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4Z9G

Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry

Summary for 4Z9G
Entry DOI10.2210/pdb4z9g/pdb
Related4K5Y
DescriptorCorticotropin-releasing factor receptor 1,Lysozyme,Corticotropin-releasing factor receptor 1, OLEIC ACID, 3,6-dimethyl-N-(pentan-3-yl)-2-(2,4,6-trimethylphenoxy)pyridin-4-amine, ... (4 entities in total)
Functional Keywords7tm, gpcr, family b, signaling protein, g-protein, membrane, membrane protein, receptor, tncs, hexagonal
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane; Multi-pass membrane protein: P34998
Total number of polymer chains3
Total formula weight156023.79
Authors
Dore, A.S.,Bortolato, A.,Hollenstein, K.,Cheng, R.K.Y.,Read, R.J.,Marshall, F.H. (deposition date: 2015-04-10, release date: 2016-06-29, Last modification date: 2024-01-10)
Primary citationDore, A.S.,Bortolato, A.,Hollenstein, K.,Cheng, R.K.Y.,Read, R.J.,Marshall, F.H.
Decoding Corticotropin-Releasing Factor Receptor Type 1 Crystal Structures.
Curr Mol Pharmacol, 10:334-344, 2017
Cited by
PubMed: 28183242
DOI: 10.2174/1874467210666170110114727
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.183 Å)
Structure validation

217705

건을2024-03-27부터공개중

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