4Z9G
Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry
Summary for 4Z9G
Entry DOI | 10.2210/pdb4z9g/pdb |
Related | 4K5Y |
Descriptor | Corticotropin-releasing factor receptor 1,Lysozyme,Corticotropin-releasing factor receptor 1, OLEIC ACID, 3,6-dimethyl-N-(pentan-3-yl)-2-(2,4,6-trimethylphenoxy)pyridin-4-amine, ... (4 entities in total) |
Functional Keywords | 7tm, gpcr, family b, signaling protein, g-protein, membrane, membrane protein, receptor, tncs, hexagonal |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P34998 |
Total number of polymer chains | 3 |
Total formula weight | 156023.79 |
Authors | Dore, A.S.,Bortolato, A.,Hollenstein, K.,Cheng, R.K.Y.,Read, R.J.,Marshall, F.H. (deposition date: 2015-04-10, release date: 2016-06-29, Last modification date: 2024-01-10) |
Primary citation | Dore, A.S.,Bortolato, A.,Hollenstein, K.,Cheng, R.K.Y.,Read, R.J.,Marshall, F.H. Decoding Corticotropin-Releasing Factor Receptor Type 1 Crystal Structures. Curr Mol Pharmacol, 10:334-344, 2017 Cited by PubMed: 28183242DOI: 10.2174/1874467210666170110114727 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.183 Å) |
Structure validation
Download full validation report