4Z93

BRD4 bromodomain 2 in complex with gamma-carboline-containing compound, number 18.

4Z93 の概要

• エントリーDOI: 10.2210/pdb4z93/pdb
• 分子名称: Bromodomain-containing protein 4, 1-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indole, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bromodomain, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13734.99

構造登録者

Meagher, J.L.,Stuckey, J.A. (登録日: 2015-04-09, 公開日: 2015-07-01, 最終更新日: 2023-09-27)

• 主引用文献: Ran, X.,Zhao, Y.,Liu, L.,Bai, L.,Yang, C.Y.,Zhou, B.,Meagher, J.L.,Chinnaswamy, K.,Stuckey, J.A.,Wang, S.; Structure-Based Design of gamma-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.; J.Med.Chem., 58:4927-4939, 2015; PubMed: 26080064; DOI: 10.1021/acs.jmedchem.5b00613

実験手法

X-RAY DIFFRACTION (1.27 Å)