4Z8L

Crystal structure of DCAF1/SIV-MND VPX/MND SAMHD1 NTD ternary complex

4Z8L の概要

• エントリーDOI: 10.2210/pdb4z8l/pdb
• 分子名称: Protein VPRBP, Vpx protein, SAM domain and HD domain-containing protein, ... (5 entities in total)
• 機能のキーワード: hiv, antiviral defense, viral protein-vpx-binding protein complex, viral protein/vpx-binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 130491.18

構造登録者

Koharudin, L.M.,Wu, Y.,Calero, G.,Ahn, J.,Gronenborn, A.M. (登録日: 2015-04-09, 公開日: 2015-06-17, 最終更新日: 2023-09-27)

• 主引用文献: Wu, Y.,Koharudin, L.M.,Mehrens, J.,DeLucia, M.,Byeon, C.H.,Byeon, I.J.,Calero, G.,Ahn, J.,Gronenborn, A.M.; Structural Basis of Clade-specific Engagement of SAMHD1 (Sterile alpha Motif and Histidine/Aspartate-containing Protein 1) Restriction Factors by Lentiviral Viral Protein X (Vpx) Virulence Factors.; J.Biol.Chem., 290:17935-17945, 2015; PubMed: 26045556; DOI: 10.1074/jbc.M115.665513

実験手法

X-RAY DIFFRACTION (2.6 Å)